Changes of serum interleukin-6 in healthy pregnant women and establishment of relevant reference intervals
Yaoyang Fu1, Lingli Tang1, Min Hu1
1Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University,Changsha, Hunan, China.
Objective:
To explore the changes of serum interleukin-6 (IL-6) levels in healthy pregnant women and establish reference intervals (RIs).
Method:
According to the requirements for the RIs study model and the reference population screening criteria in C28-A3 document, Serum IL-6 levels were measured by electrochemiluminescence immunoassay in 480 healthy Chinese women, including 120 pregnant women in each of the first, second and third trimester and 120 non-pregnant women as the negative control. The establishment of RIs for IL-6 were defined using nonparametric percentile.
Results:
The RIs for serum IL-6 levels in healthy pregnant women is <4.19 pg/ml, the RIs for serum IL-6 levels in healthy pregnant women who are in the first trimester is <3.52 pg/ml, and the RIs for serum IL-6 levels in healthy pregnant women who are in the second and third trimester is <4.40 pg/ml.
Conclusions:
Serum IL-6 level in healthy pregnant women is higher than the healthy non-pregnant women, and the level of IL-6 who are in the second and third trimester is higher than those in the first. This paper successfully established RIs for serum IL-6 levels in pregnant women, providing a reference for clinical medical staff and laboratory workers.
