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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

672
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
672
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

684
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
684
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

161
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
161
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

152
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
152
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.4K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Related Experiment Video

Updated: Jan 1, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

791

Recent progress in drug delivery.

Chong Li1, Jiancheng Wang2, Yiguang Wang2

  • 1College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

Acta Pharmaceutica Sinica. B
|December 24, 2019
PubMed
Summary
This summary is machine-generated.

Drug delivery systems (DDS) enhance drug effectiveness and reduce side effects by improving absorption and targeting. Recent advances in DDS research focus on novel strategies and construction techniques for better therapeutic outcomes.

Keywords:
ApplicationBasic researchDelivery strategyDrug delivery systemPharmaceutics

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Area of Science:

  • Pharmaceutical Sciences
  • Material Sciences
  • Biomedical Sciences

Background:

  • Drug delivery systems (DDS) are crucial for optimizing therapeutic drug efficacy.
  • Challenges include poor solubility, low bioavailability, and adverse side effects.
  • Recent progress (2015-2018) has been driven by interdisciplinary advances.

Purpose of the Study:

  • To provide a concise overview of current drug delivery system research.
  • To highlight key delivery strategies and construction techniques.
  • To serve as a reference for pharmaceutical scientists in DDS design.

Main Methods:

  • Review of recent scientific literature (2015-2018).
  • Focus on delivery strategies and construction methodologies.
  • Inclusion of specific examples of drug delivery systems.

Main Results:

  • Significant progress in drug delivery systems research.
  • Advances in related fields like pharmaceutical, material, and biomedical sciences.
  • Identification of various delivery strategies and construction techniques.

Conclusions:

  • Drug delivery systems offer solutions to therapeutic challenges.
  • Interdisciplinary collaboration accelerates DDS innovation.
  • Continued research is vital for advancing DDS design and application.