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Updated: Jan 1, 2026
13:09
Mass Spectrometric Analysis of Glycosphingolipid Antigens
Published on: April 16, 2013
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Glycosphingolipids and Infection. Potential New Therapeutic Avenues
Johannes M F G Aerts1, M Artola1, M van Eijk1
1Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
Frontiers in Cell and Developmental Biology
|December 24, 2019
Summary
Glycosphingolipids (GSLs) are crucial in host-pathogen interactions and immune responses. Modulating GSL levels may offer a novel strategy to combat infections and related diseases.
Area of Science:
- Biochemistry
- Immunology
- Cell Biology
Background:
- Glycosphingolipids (GSLs) are vital sphingolipids found on cell surfaces.
- They play roles in cellular processes, including host-pathogen interactions.
- Pathogens utilize cell-surface GSLs as receptors, and lipid rafts facilitate pathogen signaling.
Purpose of the Study:
- To review the role of GSLs in infections and immune responses.
- To explore the therapeutic potential of GSL-modulating agents.
Main Methods:
- Literature review of GSL function in infection.
- Analysis of GSL metabolism and related storage disorders (glycosphingolipidoses).
- Examination of compounds that modulate GSL levels.
Main Results:
- GSLs are implicated in pathogen binding and cellular signaling during infection.
- Deficiencies in GSL-degrading enzymes lead to storage disorders.
- GSL-modulating compounds are effective in treating glycosphingolipidoses.
Conclusions:
- GSLs are key players in host-pathogen interactions and immune responses.
- Targeting GSL metabolism with specific agents presents a promising avenue for infection prevention and treatment.
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