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Related Concept Videos

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Clinical trial design data for electrocardiogram artificial intelligence-guided screening for low ejection fraction

Xiaoxi Yao1,2,3, Rozalina G McCoy1,4, Paul A Friedman3

  • 1Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

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|December 24, 2019
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Summary

This study introduces materials for the ECG AI-Guided Screening for Low Ejection Fraction (EAGLE) trial. These resources, including a clinician report and data forms, aim to integrate artificial intelligence into routine practice for improved patient screening.

Keywords:
Artificial intelligenceClinical trialElectrocardiogramHeart failure

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Area of Science:

  • Clinical Trials
  • Artificial Intelligence in Medicine
  • Cardiology

Background:

  • Low ejection fraction (LEF) detection is crucial for cardiovascular health.
  • Integrating artificial intelligence (AI) into clinical workflows presents challenges.
  • The EAGLE trial aims to address these challenges through a pragmatic design.

Purpose of the Study:

  • To detail the materials developed for the ECG AI-Guided Screening for Low Ejection Fraction (EAGLE) trial.
  • To describe a clinician-facing report designed to translate AI algorithms into routine practice.
  • To present data collection forms for evaluating AI in clinical settings.

Main Methods:

  • Development of a clinician-facing action recommendation report using a user-centered, iterative approach with physician input.
  • Creation of data collection forms tailored for the EAGLE clinical trial.
  • Design of a pragmatic cluster randomized trial for AI implementation.

Main Results:

  • The EAGLE trial materials facilitate the translation of AI algorithms into clinical practice.
  • The developed report and forms support routine screening and alert mechanisms for positive results.
  • The materials are adaptable for other AI-driven clinical trials.

Conclusions:

  • The EAGLE trial materials provide a framework for implementing AI-driven screening tools.
  • User-centered design is key to successful AI integration in healthcare.
  • These adaptable resources can accelerate the adoption of AI in various clinical research settings.