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Published on: October 21, 2018
A risk scoring system for the decreased glomerular filtration rate in Chinese general population
Yan Gu1,2, Min Chen1, Bei Zhu1
1Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Insights
This study developed a risk scoring system to identify decreased glomerular filtration rate (GFR) in the Chinese population. The system effectively stratifies risk based on age, sex, and homocysteine levels.
Area of Science:
- Nephrology
- Public Health
- Biostatistics
Background:
- Decreased glomerular filtration rate (GFR) is a significant public health concern.
- Accurate risk stratification is crucial for early intervention in the Chinese general population.
Purpose of the Study:
- To develop and validate a risk scoring system for predicting decreased GFR.
- To enable specific risk stratification for GFR reduction in Chinese adults.
Main Methods:
- Multivariable logistic regression analysis was used to identify significant risk factors.
- A scoring system was created based on the odds ratios of identified variables.
- Participants were categorized into four risk groups based on their scores.
Main Results:
- Abnormal homocysteine levels, male sex, and older age (≥46 years) were significant predictors of reduced GFR.
- The prevalence of decreased GFR increased progressively with higher risk scores.
- The scoring system demonstrated a clear correlation between risk score and GFR reduction prevalence.
Conclusions:
- A novel risk scoring system for decreased GFR has been established for the Chinese general population.
- This tool facilitates targeted risk assessment and management strategies.
- The system provides a valuable method for GFR reduction risk stratification.
Objective:
The aim of this study was to establish a risk scoring system for the decreased glomerular filtration rate (GFR) in Chinese general population.
Methods:
Totally 781 participants who underwent a health checkup in The First Affiliated Hospital of Nanjing Medical University from January to September 2017 were involved in the study. Significant variables chosen by multivariable logistic regression analysis were allocated the integral scores in proportion to its odds ratio (OR), and then the risk of decreased GFR was assessed based on the scores.
Results:
The people with abnormal homocysteine (Hcy) level (OR: 1.534, 95% confidential interval [CI]: 1.075-2.190, P = .018), males (OR: 2.054, 95%CI: 1.365-3.092, P < .001), and those at the age of 46-52 years (OR: 2.943, 95%CI: 1.546-5.605, P = .001), 52-59 years (OR: 3.664, 95%CI: 1.937-6.931, P < .001) and ≥59 years (OR: 13.452, 95%CI: 7.339-24.657, P < .001) were subjected to GFR reduction. These three variables were allocated the integral scores in proportion to its OR, and four risk categories were divided according to the scores. The prevalence of the decreased GFR in people with low (score 0-4, n = 8), below the average (score 4-6, n = 37), above the average (score 6-13, n = 47), and high risks (score ≥ 13, n = 103) was 5.26%, 16.89%, 22.93% and 50.24%, respectively, and this prevalence raised with the increase of scores (P < .001).
Conclusions:
A risk scoring system is developed in this study, which may offer a specific risk stratification for GFR reduction in Chinese general population.
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