Related Experiment Video

Updated: Jan 1, 2026

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
06:16

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration

Published on: May 29, 2015

8.7K

Heart-lung transplantation: A viable option for connective tissue diseases

Lily K Stern1, Van N Selby2, Nicholas A Kolaitis3

  • 1Department of Medicine, University of California San Francisco, San Francisco, California.

Clinical Transplantation
|December 24, 2019
PubMed

Insights

Heart-lung transplantation (HLTx) in connective tissue disease (CTD) patients is a viable option. Outcomes for HLTx in CTD patients are comparable to lung transplantation (LTx) in CTD patients and HLTx in other conditions.

Area of Science:

  • Cardiology
  • Pulmonology
  • Transplantation Medicine
  • Rheumatology

Background:

  • Lung transplantation (LTx) is established for connective tissue disease (CTD) with pulmonary issues.
  • Outcomes for heart-lung transplantation (HLTx) in CTD patients are less understood.
  • This study evaluates HLTx efficacy in CTD patients using the UNOS database.

Purpose of the Study:

  • To assess the outcomes of heart-lung transplantation (HLTx) in patients with connective tissue disease (CTD).
  • To compare HLTx in CTD patients against lung transplantation (LTx) in CTD patients and HLTx in other indications.
  • To determine the graft survival rates and pre-transplant conditions for HLTx-CTD patients.

Main Methods:

  • Retrospective analysis of the UNOS database from 1999 to 2018.
  • Comparison of HLTx patients with CTD (HLTx-CTD) to LTx patients with CTD (LTx-CTD) and HLTx patients with other indications (HLTx-OI).
  • Evaluation of primary outcomes (1- and 5-year graft survival) and secondary outcomes (rejection rates, pre-transplant discharge status).

Main Results:

  • 17 HLTx-CTD patients were identified, comprising 3.3% of total HLTx.
  • HLTx-CTD patients exhibited worse pre-transplant hemodynamic values compared to LTx-CTD patients.
  • 1- and 5-year graft survival for HLTx-CTD was similar to LTx-CTD and HLTx-OI groups.

Conclusions:

  • Heart-lung transplantation (HLTx) is a valid option for select CTD patients with cardiac and pulmonary involvement.
  • HLTx in CTD patients demonstrates comparable morbidity and mortality to LTx in CTD patients and HLTx in other conditions.
  • Careful patient selection is crucial for successful HLTx outcomes in CTD.
Abstract

Keywords:
Sjogren's syndromeUNOS reviewconnective tissue diseasesdermatomyositisdouble organ transplantationheart-lung transplantationlung transplantationmixed connective tissue diseasepolymyositisrheumatoid arthritissclerodermasystemic lupus erythematosussystemic sclerosistransplantation

More Related Videos

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice12:24

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

9.6K
A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model06:45

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

Published on: February 7, 2022

4.0K

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
831
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
400
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
274
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
780