Motion and eddy current-induced signal dephasing in in vivo cardiac DTI

To address motion in cardiac DWI, stimulated-echo acquisition mode (STEAM) and second-order motion-compensated spin-echo (SE) sequences have been proposed. Despite applying motion-compensation strategies, residual motion can cause misleading signal attenuation. The purpose of this study is to estimate the motion-induced error in both sequences by analysis of image phase.

Diffusion-weighted motion-compensated SE sequences and STEAM imaging was applied in vivo with diffusion encoding along 3 orthogonal directions. A b-value range of 100 to 600 s/mm² and trigger delays of 25%, 50%, and 75% of end systole and middiastole were used. Eddy-current contributions were obtained from phantom measurements. After computation of motion-induced phase maps, the amount of signal dephasing was computed from phase gradients, and the resulting errors in diffusion tensor parameters were calculated.

Motion-induced dephasing from the STEAM sequence showed less dependency on the b-value and no dependency on the heart phase, whereas SE imaging performed best at 75% end systole followed by 50% end systole and middiastole. For a typical experimental setting, errors of 3.3%/3.0% mean diffusivity, 4.9%/4.8% fractional anisotropy, 2.9º/3.2º helix angulation, 0.8º/0.7º transverse angulation, and 9.9º/10.0º sheet angulation (SE/STEAM) were calculated.

Image phase contains valuable information regarding uncompensated motion and eddy currents in cardiac DTI. Although the trigger delay window for SE is narrower compared with the STEAM-based approach, imaging in both systole and diastole is feasible and both sequences perform similarly if the trigger delays are selected carefully with SE.