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Related Concept Videos

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Antimicrobial Light-Activated Polypropylene Modified with Chitosan: Characterization and Reusability.

Andrew T Gagon1, David W Britt2, Luis J Bastarrachea1

  • 1Department of Nutrition, Dietetics and Food Sciences, Utah State University, 8700 Old Main Hill, Logan, Utah 84322, United States.

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|December 24, 2019
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Summary
This summary is machine-generated.

A new reusable antimicrobial plastic activated by light was developed using chitosan. This material effectively reduced bacteria by over 94% across 10 uses, showing promise for durable antimicrobial applications.

Keywords:
chitosanlight-activated antimicrobialspolycationsreusable antimicrobial materials

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Area of Science:

  • Materials Science
  • Biotechnology
  • Polymer Chemistry

Background:

  • Chitosan is a natural polycationic compound with inherent antimicrobial properties.
  • Developing stable, reusable, and light-activated antimicrobial materials is crucial for various applications.
  • Reactive blending offers a method for creating robust composite materials.

Purpose of the Study:

  • To prepare a robust, stable, and reusable light-activated antimicrobial plastic using reactive blending.
  • To evaluate the antimicrobial efficacy of the prepared plastic against Escherichia coli K12 under UV-A light exposure.
  • To investigate the durability and mechanism of the antimicrobial action over multiple cycles.

Main Methods:

  • Reactive blending of polypropylene, maleic anhydride-grafted vinyl ether, and chitosan.
  • Antimicrobial challenge testing against Escherichia coli K12 with simultaneous UV-A light exposure.
  • Repetitive testing over 10 cycles to assess reusability and durability.
  • Surface chemistry analysis using Infrared spectroscopy.
  • Mechanism investigation via fluorometric evaluation for reactive oxygen species (ROS) generation.
  • Microscopic techniques (SEM) to assess bacterial morphology and material fouling.

Main Results:

  • A stable, light-activated antimicrobial plastic (PP-MVE-CHI) was successfully prepared.
  • The plastic demonstrated significant antimicrobial efficacy, achieving a 94.0 ± 3.3% reduction in Escherichia coli K12 population over 10 cycles.
  • Antimicrobial activity was sustained across multiple reuse cycles, indicating robustness.
  • Reactive oxygen species (ROS) generation was identified as the primary mechanism of antimicrobial action.
  • Microscopic analysis revealed damage to bacterial cell morphology and no material fouling.
  • Infrared spectroscopy confirmed minimal changes to surface chemistry after 10 cycles.

Conclusions:

  • The developed light-activated antimicrobial plastic is a reusable and effective material for microbial control.
  • The material's efficacy is attributed to ROS generation under UV-A light, leading to bacterial cell damage.
  • Its stability and sustained performance over multiple cycles highlight its potential for practical antimicrobial applications.