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Related Experiment Video

Updated: Jan 1, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

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Down but not out.

Erin T Larragoite1, Adam M Spivak1

  • 1School of Medicine, University of Utah, Salt Lake City, United States.

Elife
|December 24, 2019
PubMed
Summary
This summary is machine-generated.

Early antiretroviral therapy for HIV in monkeys reduced latent viruses. However, stopping treatment showed little effect on the virus reactivating later.

Keywords:
HIVMonkeysSIVantiretroviral therapyinfectious diseaselatent reservoirmicrobiologyviral latencyvirus

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Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Human immunodeficiency virus (HIV) establishes latent reservoirs during chronic infection.
  • Antiretroviral therapy (ART) is the standard treatment for HIV.
  • Understanding the impact of early ART on viral reservoirs is crucial for HIV cure strategies.

Purpose of the Study:

  • To investigate the effect of early ART initiation on latent HIV reservoirs in a primate model.
  • To assess the impact of ART cessation on viral reactivation.

Main Methods:

  • Non-human primates were infected with simian-human immunodeficiency virus (SHIV).
  • Early ART was administered shortly after infection.
  • Viral loads, latent viral DNA, and reactivation post-cessation were monitored.

Main Results:

  • Early ART significantly reduced the number of cells containing latent SHIV DNA.
  • Viral rebound and reactivation were observed in most animals after ART cessation.
  • The level of latent virus reduction did not prevent viral reactivation.

Conclusions:

  • Initiating ART early in HIV infection can decrease the viral reservoir size.
  • Early ART alone may not be sufficient to prevent viral reactivation upon treatment interruption.
  • Further strategies are needed to achieve a functional HIV cure.