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Longitudinal Studies

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...

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Related Experiment Video

Updated: Jan 1, 2026

Home-Based Monitor for Gait and Activity Analysis

Home-Based Monitor for Gait and Activity Analysis

Published on: August 8, 2019

A Longitudinal Wearable Sensor Study in Huntington's Disease.

Karthik Dinesh¹, Christopher W Snyder², Mulin Xiong³

¹Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA.

Journal of Huntington'S Disease

|December 24, 2019

Summary

This summary is machine-generated.

Wearable sensors objectively measure Huntington's disease (HD) motor symptoms, revealing a higher truncal chorea index in HD patients. This technology enables remote monitoring and potential early detection in prodromal HD.

Keywords:

Huntington’s disease chorea gait motor activity walking speed wearable electronic devices

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Area of Science:

Neurology
Biomedical Engineering
Wearable Technology

Background:

Current Huntington's disease (HD) motor symptom assessments are subjective and infrequent.
Wearable sensors offer objective, frequent, and remote data collection for HD.
Longitudinal studies using sensors for HD motor symptoms are limited.

Purpose of the Study:

To longitudinally measure Huntington's disease (HD) motor symptoms using wearable sensors.
To develop and validate a novel "truncal Chorea Index" for remote assessment.
To analyze gait parameters and activity profiles in HD patients over time.

Main Methods:

Participants with HD, prodromal HD, and controls wore accelerometers on limbs and trunk.
Sensor data was collected during clinic visits and two-day home monitoring periods.
Linear mixed-effects models analyzed group differences, progression, and individual variability.

Main Results:

Individuals with HD exhibited a significantly higher "truncal Chorea Index" compared to controls.
HD patients showed high intra-day variability but minimal 12-month change in the truncal chorea index.
HD patients walked less, took longer steps, and spent more time lying down than controls.

Conclusions:

A novel "truncal Chorea Index" can assess truncal chorea remotely and may be present in prodromal HD.
Wearable sensors provide objective insights into reduced mobility and increased sedentary behavior in HD.
Findings support sensor use for clinical care and evaluating new HD therapies.