Related Experiment Video
Updated: Jan 1, 2026
05:55
Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
Published on: December 1, 2023
1.2K
Molecular biomarkers in multiple sclerosis.
Tjalf Ziemssen1, Katja Akgün2, Wolfgang Brück3
1MS center, Center of Clinical Neuroscience, University Clinic Carl-Gustav Carus, Dresden University of Technology, Dresden, Germany. Tjalf.Ziemssen@uniklinikum-dresden.de.
Journal of Neuroinflammation
|December 25, 2019
Summary
Multiple sclerosis biomarkers are crucial for personalized patient care. This review highlights ideal molecular biomarker characteristics and promising blood/CSF markers for MS diagnosis, prognosis, and treatment monitoring.
Area of Science:
- Neuroimmunology and Neurobiology
- Central Nervous System Inflammatory Diseases
Background:
- Multiple sclerosis (MS) is a heterogeneous inflammatory-neurodegenerative CNS disease.
- Current clinical and imaging biomarkers lack individual predictive power.
- Molecular biomarkers offer complementary insights into MS pathomechanisms.
Purpose of the Study:
- To define characteristics of an ideal MS biomarker.
- To outline challenges in establishing new MS biomarkers.
- To review clinically relevant blood and cerebrospinal fluid biomarkers for MS diagnosis, prognosis, and therapy assessment.
Main Methods:
- Literature review of MS biomarker research.
- Analysis of biomarker validation and clinical implementation challenges.
- Synthesis of data on immunological and neurobiological markers.
Main Results:
- Ideal MS biomarkers should be easily quantifiable and reflect causal pathomechanisms.
- Few molecular biomarkers are routinely used due to lengthy validation processes.
- Promising biomarkers in blood and CSF exist for diagnosis, prognosis, and treatment monitoring.
Conclusions:
- Development of ideal MS biomarkers is essential for personalized medicine.
- Overcoming validation hurdles is key to clinical translation.
- Blood and CSF biomarkers hold significant potential for improving MS management.
