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DEPICTER: Intrinsic Disorder and Disorder Function Prediction Server.

Amita Barik1, Akila Katuwawala2, Jack Hanson3

  • 1Department of Computer Science, Virginia Commonwealth University, Richmond, VA, 23284, USA; Department of Biotechnology, National Institute of Technology, Durgapur, India.

Journal of Molecular Biology
|December 25, 2019
PubMed
Summary
This summary is machine-generated.

DEPICTER offers centralized access to 10 protein disorder prediction tools, simplifying the analysis of unannotated proteins and their functions. This server provides accurate, automated predictions, improving upon traditional sequence alignment methods for protein disorder analysis.

Keywords:
intrinsically disordered proteinsintrinsically disordered regionprediction centerprotein–nucleic acids interactionswebserver

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Area of Science:

  • Computational Biology
  • Bioinformatics
  • Structural Biology

Background:

  • Millions of proteins lack functional annotation.
  • Predicting intrinsic disorder and function is crucial for protein annotation.
  • Existing disorder prediction tools are fragmented and difficult to access.

Purpose of the Study:

  • To provide a centralized server for accessing multiple disorder prediction tools.
  • To automate the prediction of protein intrinsic disorder and its functions.
  • To offer consensus predictors for disorder and disordered protein binding.

Main Methods:

  • Developed the DEPICTER (DisorderEd PredictIon CenTER) server.
  • Integrated 10 popular disorder and disorder function prediction methods.
  • Implemented server-side prediction automation, result visualization, and standardized output.
  • Included two consensus predictors for disorder and disordered protein binding.

Main Results:

  • DEPICTER provides unified access to diverse prediction tools.
  • Automated predictions cover protein/nucleic acid binding, linkers, and moonlighting regions.
  • Consensus predictors enhance disorder and binding site predictions.
  • Empirical tests show DEPICTER predictions outperform sequence alignment on independent datasets.

Conclusions:

  • DEPICTER simplifies and enhances the prediction of protein intrinsic disorder and function.
  • The server offers a valuable resource for annotating uncharacterized proteins.
  • Centralized access and automated predictions improve research efficiency in bioinformatics.