Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methadyl acetate and methadone. An open comparison.

E C Senay, W Dorus, P F Renault

    JAMA
    |January 10, 1977
    PubMed
    Summary

    This 14-week study found no significant differences in treatment outcomes between methadone hydrochloride and methadyl acetate for heroin addiction. However, methadyl acetate showed a different dropout pattern, suggesting variable induction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fantasies about the fetus in wanted and unwanted pregnancies.

    Journal of youth and adolescence·2014
    Same author

    A postmarketing surveillance program to monitor Ultram (tramadol hydrochloride) abuse in the United States.

    Drug and alcohol dependence·2000
    Same author

    Interventions/Wilmer: a continuum of care for substance abusers in the criminal justice system.

    Journal of psychoactive drugs·1995
    Same author

    Medical maintenance: an interim report.

    Journal of addictive diseases·1994
    Same author

    Medical maintenance: a pilot study.

    Journal of addictive diseases·1993
    Same author

    Low prevalence of sexual transmission of hepatitis C virus in sex partners of seropositive intravenous drug users.

    The Journal of infectious diseases·1991

    Area of Science:

    • Addiction Medicine
    • Clinical Pharmacology
    • Pharmacotherapy

    Background:

    • Opioid use disorder (OUD) treatment often involves medication-assisted treatment.
    • Methadone hydrochloride and methadyl acetate are opioid agonists used in OUD management.
    • Comparing the efficacy and safety of different pharmacotherapies is crucial for optimizing OUD treatment.

    Purpose of the Study:

    • To conduct a 14-week open clinical comparison of methadone hydrochloride and methadyl acetate for heroin addiction.
    • To evaluate retention rates, illicit drug use, employment, and arrest rates between the two treatment groups.

    Main Methods:

    • Recruitment of heroin addicts for a 14-week open clinical trial.
    • Random assignment to either a methadyl acetate clinic (three doses/week) or a methadone hydrochloride clinic (six doses/week).
    • Statistical analysis of patient outcomes including retention, drug use, employment, and arrests.

    Main Results:

    • No statistically significant differences were observed in retention rates, illicit drug use, employment, or arrest rates between methadone and methadyl acetate groups.
    • A significant difference (P = .01) in dropout patterns was noted, with methadyl acetate having more early dropouts.
    • Spontaneously reported symptoms indicated potentially more variable induction with methadyl acetate compared to methadone.

    Conclusions:

    • Methadone hydrochloride and methadyl acetate demonstrate comparable effectiveness regarding key treatment outcomes in this study.
    • Methadyl acetate's distinct dropout pattern warrants further investigation into its induction process.
    • Reducing clinic visits with methadyl acetate did not negatively impact treatment effectiveness.

    Related Experiment Videos