Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 1, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

Understanding the development of amblyopia using macaque monkey models.

Lynne Kiorpes¹

¹Center for Neural Science, New York University, New York, NY 10003.

Proceedings of the National Academy of Sciences of the United States of America

|December 25, 2019

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emergence of a contrast-invariant representation of naturalistic texture in macaque visual cortex.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Neural Sensitivity to Radial Frequency Patterns in the Visual Cortex of Developing Macaques.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Same author

Neural sensitivity to radial frequency patterns in the visual cortex of developing macaques.

bioRxiv : the preprint server for biology·2025

Same author

Opposite asymmetry in visual perception of humans and macaques.

Current biology : CB·2025

Same author

Emergence of a contrast-invariant representation of naturalistic texture in macaque visual cortex.

bioRxiv : the preprint server for biology·2025

Same author

Development of Higher-Level Vision: A Network Perspective.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024

Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026

See all related articles

Amblyopia, a developmental vision disorder in children, impacts visual acuity and brain function. Research in primate models reveals its origins and guides new treatments for this common condition.

Area of Science:

Neuroscience
Developmental Biology
Ophthalmology

Background:

Amblyopia, or "lazy eye," is a common developmental disorder affecting up to 4% of children globally.
Clinically characterized by reduced visual acuity and impaired binocular vision, it also impacts higher-level perceptual abilities.
Abnormal visual experience during critical developmental periods underlies amblyopia, affecting visual pathways from the primary visual cortex (V1) onwards.

Purpose of the Study:

To explore the neural mechanisms and developmental trajectory of amblyopia using nonhuman primate models.
To understand the full spectrum of perceptual and functional deficits associated with amblyopia.
To bridge the gap between animal model research and clinical applications for amblyopia treatment.

Main Methods:

Keywords:

amblyopia comparative vision macaque monkey nonhuman primate visual cortex

More Related Videos

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Organotypic Retinal Explant Cultures from Macaque Monkey

Organotypic Retinal Explant Cultures from Macaque Monkey

Published on: August 24, 2022

Related Experiment Videos

Last Updated: Jan 1, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Organotypic Retinal Explant Cultures from Macaque Monkey

Organotypic Retinal Explant Cultures from Macaque Monkey

Published on: August 24, 2022

Utilized nonhuman primate models to study the natural history and origins of amblyopia.
Investigated the impact of abnormal binocular visual experience on visual pathway structure and function.
Analyzed neural correlates of amblyopia in various visual processing areas, including V1 and beyond.

Main Results:

Nonhuman primate models provide critical insights into the sensitive periods and underlying brain mechanisms of amblyopia.
Amblyopia affects not only early visual processing in V1 but also higher-level visual areas, leading to complex deficits.
Abnormalities extend beyond simple transmission from earlier processing stages, indicating widespread neural impact.

Conclusions:

Research in animal models has significantly advanced our understanding of amblyopia's origins and neural basis.
The findings underscore the importance of considering the complete set of deficits for a comprehensive understanding of amblyopia.
Translational research using primate models is crucial for developing novel therapeutic strategies for amblyopia.