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Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
Calcium antagonism in isolated rat uterus by methylmethacrylate
C K Born1, M E Hamrick, C P Davidson
1Department of Pharmacal Sciences, School of Pharmacy, Auburn University, AL 36849.
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1988
Abstract:
Methylmethacrylate (MMA) was evaluated for the ability to block actions of calcium in the isolated rat uterine preparation. MMA blocked receptor-mediated contraction and the phasic and tonic portions of the KCl induced contraction of the uterus. The effects of MMA could be antagonized by increasing the concentration of calcium. In the Ca++-free, K-depolarized preparation, MMA produced dose related depression of contraction.
