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Biovailability and pulmonary first-pass removal of etretinate in rats
1Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1988
Abstract:
The oral biovailability of etretinate (ET) and its presystemic loss due to pulmonary extraction were studied in the rat. The oral biovailability was found to be 15%. The percentage of a dose of ET escaping pulmonary extraction was estimated to be 49%. These data suggest substantial presystemic loss of ET, including significant extraction by the lungs.