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Updated: Jan 1, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration
Federica Casiraghi1, Norberto Perico1, Eliana Gotti2
1Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Abstract:
Here we report the case of successful immune tolerance induction in a living-donor kidney transplant recipient remotely treated with autologous bone marrow-derived mesenchymal stromal cells (MSC). This case report, which to the best of our knowledge is the first in the world in this setting, provides evidence that the modulation of the host immune system with MSC can enable the safe withdrawal of maintenance immunosuppressive drugs while preserving optimal long-term kidney allograft function.
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