Related Experiment Video
Updated: Jan 1, 2026

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
Published on: April 26, 2018
Development of a deep-red fluorescent glucose-conjugated bioprobe for in vivo tumor targeting
Yinwei Cheng1, Ghulam Shabir, Xiang Li
1Department of Biochemistry and Molecular Biology, Comprehensive Building, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, P. R. China. nmli@stu.edu.cn lyxu@stu.edu.cn.
Abstract:
A C1-type d-glucose-conjugated fluorescent probe Glu-1-O-DCSN was synthesized and showed deep-red emission at 685 nm with a Stokes shift of up to 150 nm in DMSO. In in vitro live cell imaging, Glu-1-O-DCSN exhibited similar and competitive uptake behaviours to d-glucose and was selectively located in mitochondria. Furthermore, Glu-1-O-DCSN was successfully employed for in vivo hypermetabolic tumor targeting.

