Temperature estimation of inflamed bowel by the photoacoustic inverse approach

Local temperature increase is one of the five classical signs of regions with inflammations. This work is focused on the application of the photoacoustic technique for the estimation of the temperature field in the colon, as the solution of an inverse problem, for the detection of inflamed regions. Two-dimensional cases are examined here involving a cross section of the bowel, which characterize either the inflammation of the whole mucosa layer, or three small inflamed regions. The inverse problem is solved for a rotating laser inside the intestine lumen, which imposes pulses for the generation of the acoustic waves. One single ultrasound detector, also located at the laser rotating shaft, provides the simulated measurements for the inverse analysis. The inverse problem is solved here with the minimization of the maximum a posteriori objective function. Results show that the proposed technique can be applied for accurate estimations of the temperature distribution in the region of interest, which might be used for the diagnosis of inflammatory bowel diseases (IBD).