Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC No. 5416

Three undescribed chromanones (1-3) and two known chromanones (4 and 5) were isolated from the culture of endophytic fungus Phomopsis CGMCC No. 5416 from the stems of Achyranthes bidentata. Their structures were determined by spectroscopic analysis. Compounds 1 and 2 showed inhibitory activities against HIV-1 with IC₅₀ values of 20.4 and 32.5 μg ml^-1, respectively. Compounds 1-3 displayed moderate cytotoxicity with CC₅₀ values of 36.5-79.3 μg ml^-1 against A549, MDA-MB-231, and PANC-1 cell lines. Moreover, compound 3 can induce the early apoptosis of PANC-1 cancer cells with the apoptosis rate of 10.52%.