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Utility of PET/CT in patients with stage I-III melanoma
J A Avilés Izquierdo1, I Molina López2, P Sobrini Morillo3
1Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Calle Dr Esquerdo 46, 28007, Madrid, Spain. jaavilesizquierdo@gmail.com.
Purpose:
To study the utility of positron emission tomography with computerized tomography (PET/CT) in patients with a stage I-III melanoma.
Patients And Methods:
PET/CT findings from all patients with a stage I-III melanoma attended at our hospital from September 2011 to November 2015 were reviewed.
Results:
Data from 83 patients with a stage I-III melanoma, 39 patients with a positive sentinel lymph node biopsy (SLNB) and 35 patients with locoregional recurrences were analyzed. Sensitivity of PET/CT in clinical stage I-III patients was 5%, with a 14% of false positives. In patients with a positive SLNB, PET/CT previous to complete lymph node dissection had a 23% of false negatives. In patients with clinical locoregional recurrences, PET/CT findings revealed asymptomatic visceral distant metastasis in 25.7%.
Conclusions:
PET/CT has a significant rate of false positive and negative results in patients with a stage I-III melanoma. Utility in patients with nodal locoregional recurrences seems higher than in patients with skin metastases.
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