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An approach to explore for a sweet spot in randomized trials

Donald A Redelmeier1, Robert J Tibshirani2

  • 1Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Evaluative Clinical Sciences Department, Sunnybrook Research Institute, Toronto, Ontario, Canada; Population and Global Health Department, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Division of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Center for Leading Injury Prevention Practice Education & Research, Toronto, Ontario, Canada.

Journal of Clinical Epidemiology
|December 25, 2019
PubMed
Summary

Analyzing randomized trials using stratified methods can reveal a "sweet spot" for treatment benefits. This approach highlights where specific patient groups, like those with moderate disease severity, experience accentuated survival advantages.

Keywords:
Cardiac defibrillatorClinical trialsHeterogeneous treatment effectPatient diversityPrecision medicineSudden death

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