Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-risk Category II electronic fetal monitoring features in the first stage of labor is a risk factor for neonatal acidemia.

American journal of obstetrics & gynecology MFM·2026
Same author

Patient-Centered Prescription Opioid Tapering Methods : A Randomized Clinical Trial.

Annals of internal medicine·2026
Same author

The human claustrum supports cognitive networks for externally and internally driven task demands.

PLoS biology·2026
Same author

Understanding Motor Adaptation in the Transition to Sustained Pain: Protocol for a Longitudinal Experimental Study.

JMIR research protocols·2026
Same author

Maternal cardiometabolic health and the role of GLP-1 receptor agonists from preconception to postpartum: A review of evidence and opportunities.

American journal of preventive cardiology·2026
Same author

Prepregnancy obesity, gestational weight gain, and their relationship with maternal lipid levels at delivery across racial and ethnic populations.

American journal of physiology. Heart and circulatory physiology·2026

Related Experiment Video

Updated: Jan 1, 2026

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.7K

Neural and behavioral changes driven by observationally-induced hypoalgesia.

Nandini Raghuraman1, Yang Wang1, Lieven A Schenk2

  • 1Department of Pain and Translational Symptom Sciences University of Maryland School of Nursing, Baltimore, MD, USA.

Scientific Reports
|December 26, 2019
PubMed
Summary

Observing others receive pain relief can reduce your own pain through social learning. This study used EEG to show that observing pain relief activates anticipatory neural processes, influencing placebo effects.

More Related Videos

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

34.0K
An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae
07:17

An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae

Published on: October 29, 2020

5.1K

Related Experiment Videos

Last Updated: Jan 1, 2026

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.7K
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

34.0K
An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae
07:17

An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae

Published on: October 29, 2020

5.1K

Area of Science:

  • Neuroscience
  • Psychology
  • Pain Research

Background:

  • Social learning and observation are known to influence placebo hypoalgesia.
  • Observing successful pain treatment in others can trigger anticipatory neural activity, leading to pain relief.

Purpose of the Study:

  • To investigate the neurophysiological changes associated with pain relief acquired through observation using electroencephalography (EEG).
  • To explore the role of anticipatory mechanisms and attentional processes in observationally-induced placebo hypoalgesia.

Main Methods:

  • Thirty-one participants observed a demonstrator receiving painful heat stimuli paired with a 'control' cream and non-painful stimuli with a 'treatment' cream (both Vanicreams).
  • Participants later received the same creams and stimuli, with EEG recording to measure neurophysiological responses.
  • Analysis focused on P2 component changes, brain region activity (right middle frontal gyrus), and correlation with resting state peak alpha frequency (PAF) in placebo responders.

Main Results:

  • The 'treatment' cream resulted in significantly lower self-reported pain intensity compared to the 'control' cream.
  • Anticipatory cues for the 'treatment' cream elicited a smaller P2 component in specific frontal electrodes (F1, Fz, FC1, FCz), indicating modulated attentional engagement.
  • In placebo responders, hypoalgesia correlated positively with resting state peak alpha frequency (PAF) in sensorimotor cortex electrodes (C3, Cz, C4).

Conclusions:

  • Observationally-induced placebo hypoalgesia appears to be driven by anticipatory mechanisms that modulate frontal attentional processes.
  • Resting state peak alpha frequency (PAF) may serve as a predictor for the efficacy of observationally-induced placebo hypoalgesia.