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Fluids affecting bladder urgency and lower urinary symptoms (FABULUS): methods and protocol for a randomized

Megan O Schimpf1, Abigail R Smith2, Janis M Miller3,4

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Summary

Reducing potentially irritating beverages (PIBs) may decrease urinary frequency in women with overactive bladder (OAB). This study tested lifestyle changes for OAB symptom management.

Keywords:
Bladder irritantsLower urinary tract symptomsOveractive bladderRandomized controlled trialUrinary urgency

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Area of Science:

  • Urology
  • Clinical Trials
  • Behavioral Medicine

Background:

  • Overactive bladder (OAB) significantly impacts quality of life.
  • Current OAB treatments have associated costs and side effects.
  • Lifestyle modifications may offer a safer alternative for OAB management.

Purpose of the Study:

  • To evaluate the effectiveness of reducing potentially irritating beverages (PIBs) in managing overactive bladder (OAB) symptoms.
  • To compare the impact of PIB reduction versus diet/exercise recommendations on urinary void frequency.
  • To assess changes in urgency symptoms and voided volume as secondary outcomes.

Main Methods:

  • Design of the Fluids Affecting Bladder Urgency and Lower Urinary Symptoms (FABULUS) randomized controlled trial.
  • Use of standardized automated tutorials to enhance participant compliance with study protocols.
  • Intervention group focused on eliminating PIBs while maintaining consistent fluid intake; control group received diet/exercise advice.

Main Results:

  • Study results are anticipated to inform the efficacy of a tutorial-based approach for PIB reduction in OAB treatment.
  • Findings will provide insights into the effectiveness of specific PIB elimination strategies for managing OAB symptoms.

Conclusions:

  • Effective lifestyle interventions for OAB could lead to significant public health benefits.
  • Simple dietary changes, like reducing PIBs, may improve or prevent bladder symptoms, reducing reliance on medication.