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[XP gene polymorphisms and haplotypes with genetic susceptibility to lung cancer]
Yijiang Huang1, Chong Meng2, Wenfang Long1
1School of Public Health, Hainan Medical College, Haikou 571199, China.
Specific gene polymorphisms in XPB and XPG are linked to increased lung cancer risk. These DNA repair gene variations, including rs4150434 (XPB) and rs4771436/rs2094258 (XPG), highlight potential genetic susceptibility factors.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- DNA repair genes play a crucial role in maintaining genomic stability.
- Defects in DNA repair mechanisms are implicated in cancer development.
- Specific gene polymorphisms may alter DNA repair efficiency, influencing cancer susceptibility.
Purpose of the Study:
- To investigate the association between DNA repair gene (XPB, XPD, XPG) polymorphisms and haplotypes and genetic susceptibility to lung cancer.
- To identify specific genetic markers that may confer increased risk for lung cancer.
Main Methods:
- A case-control study involving 100 lung cancer patients and 100 respiratory disease controls from Hainan Province.
- Genotyping of XPB (rs4150441, rs4150434), XPD (rs171140, rs11878544), and XPG (rs4771436, rs2094258, rs17655) gene polymorphisms using mass spectrometry.
- Haplotype analysis using Halopview software to assess combined effects of linked polymorphisms.
Main Results:
- Significant associations were found between XPB rs4150434, XPG rs4771436, and XPG rs2094258 polymorphisms and lung cancer susceptibility (P < 0.05).
- Carriers of specific genotypes at these loci exhibited increased lung cancer risk (e.g., XPB rs4150434 GA/AA: OR 2.071-2.535; XPG rs4771436 GG: OR 2.494; XPG rs2094258 AA: OR 3.020).
- Haplotype analysis revealed increased lung cancer risk associated with XPB rs4150441-rs4150434 GA (OR 3.643) and XPG rs2094258-rs4771436-rs17655 ATC (OR 3.800) haplotypes.
Conclusions:
- Polymorphisms in XPB (rs4150434) and XPG (rs4771436, rs2094258) are associated with genetic susceptibility to lung cancer.
- Specific haplotypes within XPB and XPG genes also correlate with altered lung cancer risk.
- These findings suggest that variations in DNA repair genes contribute to individual susceptibility to lung cancer.
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