Computerized Analysis of Brain MRI Parameter Dynamics in Young Patients With Cushing Syndrome-A Case-Control Study.

Area of Science:

• Neuroendocrinology
• Radiology
• Pediatric Endocrinology

Background:

• Young patients with Cushing Syndrome (CS) may experience cognitive and behavioral changes.
• Understanding the brain's structural alterations in CS is crucial for managing pediatric patients.

Purpose of the Study:

• To investigate the effects of Cushing Syndrome (CS) on brain structure and dynamics using MRI.
• To correlate brain imaging findings with cortisol levels and CS disease status (persistent vs. resolved).

Main Methods:

• Analyzed serial MRI scans from patients with CS (n=29) and controls (n=8).
• Assessed total and gray/white matter (GM/WM) volumes and intensities, and cortical parameters.
• Examined parameter dynamics in relation to cortisol levels and CS status.

Main Results:

• Elevated cortisol correlated inversely with subcortical GM, corpus callosum, and cerebral WM intensity.
• Cortisol dynamics negatively correlated with volume changes in multiple brain structures.
• Persistent CS showed altered cortical thickness and WM intensity/volume dynamics compared to resolved CS and controls.

Conclusions:

• Brain WM/GM consistency, intensity, and homogeneity changes in CS patients may be more indicative of clinical consequences than volume dynamics alone.
• MRI-based assessment of brain tissue characteristics offers valuable insights into CS-related neurological impact.