Related Experiment Video
Updated: Jan 1, 2026

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
Recurrent Pneumococcal Meningitis Secondary to Nasoethmoidal Meningocele
Amanda Taylor1, Graeme van der Meer2, David Perry3
1From the Department of Paediatric Medicine, Kidz First Children's Hospital, Counties Manukau District Health board, Auckland, New Zealand.
Insights
Recurrent pneumococcal meningitis in children may signal hidden skull base defects. Advanced neuroimaging is crucial for identifying these subtle abnormalities, even after initial investigations.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Background:
- The conjugate pneumococcal vaccine has reduced invasive pneumococcal disease in children.
- A significant number of pediatric pneumococcal meningitis cases involve underlying immunodeficiency or anatomical issues.
Abstract:
Since the widespread introduction of the conjugate pneumococcal vaccine and subsequent decline of invasive pneumococcal disease in children, a significant proportion of children with pneumococcal meningitis are identified as having an underlying immunodeficiency or predisposing anatomic abnormality. We present 3 cases of recurrent pneumococcal meningitis where detailed neuro-imaging revealed subtle anterior base of skull defects not detected on initial investigations.
More Related Videos
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Related Concept Videos
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumothorax-II
Clinical Manifestations:
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Pneumonia III: Complications and Assessment
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Nose and Nasal Cavity