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Rhinovirus C Is Associated With Severe Wheezing and Febrile Respiratory Illness in Young Children

Riku Erkkola1, Riitta Turunen2, Kati Räisänen3

  • 1From the Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.

The Pediatric Infectious Disease Journal
|December 27, 2019
PubMed

Insights

Rhinovirus C is the most common cause of severe respiratory illness in children, including wheezing and fever. Atopic eczema history also correlates with increased wheezing severity in these infections.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Respiratory medicine

Background:

  • Rhinoviruses are the leading cause of respiratory tract infections in children.
  • Rhinoviruses are categorized into three species: A, B, and C.
  • Understanding the specific impact of each rhinovirus species on illness severity is crucial.

Purpose of the Study:

  • To investigate the associations between different rhinovirus species and the severity of respiratory illnesses in young children.
  • To determine if specific rhinovirus species are linked to more severe clinical outcomes.

Main Methods:

  • A retrospective observational cohort study was conducted.
  • Data included 134 children aged 3-23 months with confirmed rhinovirus infections.
  • Children were participants in concurrent prospective studies on bronchiolitis and acute otitis media.

Main Results:

  • Rhinovirus C was the most prevalent species identified in the study cohort.
  • Rhinovirus C infection was significantly associated with severe wheezing and febrile illness.
  • A history of atopic eczema was also found to be associated with wheezing.

Conclusions:

  • The findings reinforce the understanding of Rhinovirus C as a highly pathogenic rhinovirus species.
  • The study supports existing research linking atopic characteristics to increased severity of Rhinovirus C-induced respiratory illness.
Abstract

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