Related Experiment Video

Updated: Jan 1, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

41.3K

Plasma D-dimer as a novel biomarker for predicting poor outcomes in HBV-related decompensated cirrhosis

Jing Zhou1, WeiLin Mao2,3, LiangJun Shen1

  • 1Department of Brain Surgery, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou.

Medicine
|December 27, 2019
PubMed

Insights

Plasma D-dimer levels show promise as a prognostic biomarker for predicting short-term mortality in patients with hepatitis B virus-related decompensated cirrhosis. Elevated D-dimer levels independently predict 1-month mortality in this patient group.

Area of Science:

  • Hepatology
  • Biomarker Discovery
  • Clinical Medicine

Background:

  • Hepatitis B virus-related decompensated cirrhosis (HBV-DeCi) carries a significant risk of short-term mortality.
  • Identifying reliable prognostic biomarkers is crucial for timely intervention in HBV-DeCi patients.

Purpose of the Study:

  • To investigate the potential of plasma D-dimer levels as a novel prognostic biomarker for 1-month mortality in HBV-DeCi patients.
  • To compare the predictive value of D-dimer with established prognostic scores.

Main Methods:

  • Retrospective analysis of 132 HBV-DeCi patients.
  • Univariate and multivariate regression models to identify mortality risk factors.
  • Receiver operating characteristic (ROC) curve analysis to assess predictive accuracy.

Main Results:

  • Plasma D-dimer levels were significantly higher in non-survivors compared to survivors.
  • D-dimer levels showed a positive correlation with the Model for End-Stage Liver Disease (MELD) score.
  • Multivariate analysis confirmed D-dimer and MELD score as independent predictors of 1-month mortality (P < .01).

Conclusions:

  • Plasma D-dimer is a novel and valuable prognostic marker for predicting 1-month mortality in HBV-DeCi patients.
  • D-dimer can serve as an additional tool alongside MELD score for risk stratification.

More Related Videos

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System05:55

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System

Published on: December 21, 2019

7.1K
Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

22.3K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
140
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
241
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.5K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
237
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
174