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Features of ectopic lymphoid-like structures in human uveitis.
Simon J Epps1, Natalie Coplin2, Philip J Luthert3
1School of Clinical Sciences, University of Bristol, UK.
Experimental Eye Research
|December 27, 2019
Summary
Chronic persistent uveitis can cause immune cells to form abnormal structures in the eye. These ectopic lymphoid-like structures may be a target for new treatments for antibody-related eye inflammation.
Area of Science:
- Ophthalmology
- Immunology
- Pathology
Background:
- Persistent non-infectious uveitis causes significant morbidity.
- The role of inflammation-driven tissue remodeling in uveitis is not fully understood.
Purpose of the Study:
- To investigate ocular tissue remodeling and immune responses in chronic persistent uveitis.
- To identify potential therapeutic targets for uveitis.
Main Methods:
- Analysis of 15 ocular tissue samples from patients with focal infiltration.
- Immunohistochemical identification of B cells (CD20+) and T cells (CD3+).
- Transcriptomic analysis of 520 immune-relevant genes.
Main Results:
- Eleven of fifteen samples showed lymphocyte infiltration, including B and T cells.
- Ectopic lymphoid-like structures were observed in 20% of samples.
- 24 immune-related genes were upregulated, with CD14 and fibronectin elevated compared to control tissues.
Conclusions:
- Chronic uveitis can lead to dysregulated ocular immune surveillance.
- Ectopic lymphoid-like structures in the eye may represent a therapeutic target.
- Targeting antibody-producing cells could be beneficial in treating persistent uveitis.
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