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Updated: Jan 1, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Recent developments of chalcones as potential antibacterial agents in medicinal chemistry
1Key Laboratory of Biological Medicine in Universities of Shandong Province, School of Bioscience and Technology, Weifang Medical University, Shandong, China.
Abstract:
Chalcones, containing an α,β-unsaturated ketone fragment, are an important pharmacologically active agents because of their diverse mechanisms. This review provides an update on the recent developments (2009-2019.3) in the antibacterial activity of natural and synthetic chalcones. Moreover, the structure-activity relationships and mechanisms are also carefully summarized which will provide some important guidance for design and synthesis in future. This comprehensive and critical review will be helpful for medicinal chemists to develop more candidate antibacterial agents.
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