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Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial

Byung Chul Yu1, Nam-Jun Cho2, Samel Park2

  • 1Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Bucheon 14584, Korea.

Journal of Clinical Medicine
|December 28, 2019
PubMed

Insights

Minor glomerular abnormalities (MGAs) indicate kidney damage and are linked to worsening kidney function and increased urinary mitochondrial DNA (mtDNA) copy numbers, similar to IgA nephropathy. Close patient follow-up is recommended.

Area of Science:

  • Nephrology
  • Pathology
  • Genetics

Background:

  • Minor glomerular abnormalities (MGAs) are unclassified glomerular lesions lacking defined long-term outcomes or pathogenesis.
  • Previous research has not extensively examined the clinical trajectory or underlying mechanisms of MGAs.

Purpose of the Study:

  • To investigate the long-term clinical outcomes of MGAs.
  • To assess the association between MGAs and kidney function deterioration.
  • To evaluate urinary mitochondrial DNA (mtDNA) copy numbers in patients with MGAs.

Main Methods:

  • Retrospective analysis of patients with MGAs, IgA nephropathy (IgAN), and matched healthy controls (MHCs) to assess estimated glomerular filtration rate (eGFR) decline.
  • Prospective analysis comparing urinary mtDNA copy numbers in patients with MGAs, IgAN, and MHCs.

Main Results:

  • Both MGA and IgAN groups showed significant differences in eGFR time-course effects and higher mean annual eGFR decline rates compared to MHCs.
  • Urinary mtDNA copy numbers were elevated in both MGA and IgAN groups relative to MHCs.
  • No significant differences in eGFR decline or urinary mtDNA copy numbers were observed between the MGA and IgAN groups.

Conclusions:

  • MGAs are associated with progressive kidney function decline and evidence of mitochondrial injury.
  • Despite minimal pathological changes, MGAs share similar clinical trajectories and biomarkers with IgA nephropathy.
  • Long-term monitoring of patients with MGAs is clinically warranted.
Keywords:
glomerular filtration rateglomerulonephritisminor glomerular abnormalitiesmitochondrial injuryurinary mitochondrial DNA

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