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Honokiol: A Review of Its Anticancer Potential and Mechanisms

Chon Phin Ong1, Wai Leong Lee1, Yin Quan Tang1

  • 1School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University Lakeside Campus, No. 1, Jalan Taylor's, 47500 Subang Jaya, Malaysia.

Cancers
|December 28, 2019
PubMed

Insights

Honokiol, a natural compound from Magnolia species, shows significant anticancer potential by regulating cell cycle, inhibiting metastasis, and reducing angiogenesis. It offers a promising avenue for cancer chemoprevention and treatment with potentially fewer side effects.

Area of Science:

  • Natural Product Chemistry
  • Molecular Oncology
  • Pharmacology

Background:

  • Cancer arises from uncontrolled cell division due to gene mutations, with increasing drug resistance necessitating novel treatments.
  • Natural products offer unique chemical structures effective against cancer with potentially fewer side effects than conventional therapies.

Purpose of the Study:

  • To review the anticancer properties and mechanisms of honokiol, a bioactive compound from Magnolia species.
  • To explore honokiol's potential as a chemopreventive and therapeutic agent for cancer.

Main Methods:

  • Literature review of studies investigating honokiol's effects on cancer cells and in vivo models.
  • Analysis of honokiol's impact on key cancer signaling pathways, including cell cycle regulation, epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis.

Main Results:

  • Honokiol induces G0/G1 and G2/M cell cycle arrest by regulating cyclin-dependent kinases and cyclins.
  • It inhibits epithelial-mesenchymal transition, cell migration, and invasion by modulating specific markers and signaling pathways (AMPK, KISS1/KISS1R).
  • Honokiol exhibits anti-angiogenesis activity through downregulation of vascular endothelial growth factor (VEGF) and its receptor (VEGFR).

Conclusions:

  • Honokiol demonstrates broad-spectrum anticancer activity through multiple molecular targets.
  • Its ability to regulate critical cancer processes positions it as a promising candidate for cancer chemoprevention and treatment.
Keywords:
anticancerhonokiolmechanismsignalling pathway

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