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TRPC Channels in Proteinuric Kidney Diseases
Gentzon Hall1, Liming Wang1, Robert F Spurney1
1Division of Nephrology, Department of Medicine, Duke University; Durham, NC 27710, USA.
Cells
|December 28, 2019
Summary
Transient Receptor Potential Cation Channel 6 (TRPC6) mutations cause familial nephrosis. TRPC6 and related channels are key targets for treating kidney diseases like FSGS and diabetic nephropathy.
Area of Science:
- Nephrology
- Molecular Biology
- Physiology
Background:
- Mutations in Transient Receptor Potential Cation Channel 6 (TRPC6) are linked to familial nephrosis.
- TRPC6 is implicated in the pathophysiology of various non-genetic kidney diseases, including FSGS, diabetic nephropathy, and renal fibrosis.
- TRPC6 is a significant target for therapeutic development in kidney disease.
Purpose of the Study:
- To review the role of TRPC6 and other TRPC family members in genetic and non-genetic kidney diseases.
- To focus on the involvement of TRPC3, TRPC5, and TRPC6 in glomerular podocytes.
- To highlight the significance of TRPC channels in proteinuric kidney diseases and chronic kidney disease (CKD).
Main Methods:
- Literature review of studies on TRPC channel function in kidney disease.
- Analysis of data implicating TRPC6 in familial and non-familial kidney pathologies.
- Focus on the role of TRPC3, TRPC5, and TRPC6 in glomerular podocytes.
Main Results:
- TRPC6 mutations are a cause of familial nephrosis.
- TRPC6 is involved in the progression of FSGS, diabetic nephropathy, and renal fibrosis.
- Other TRPC channels (TRPC3, TRPC5) also contribute to glomerular disease and CKD.
Conclusions:
- TRPC6 is a critical factor in various kidney diseases.
- TRPC3, TRPC5, and TRPC6 are implicated in podocyte dysfunction and proteinuric kidney diseases.
- TRPC channels represent promising therapeutic targets for diverse kidney conditions.
Keywords:
TRPC channelTRPC3TRPC5TRPC6chronic kidney diseasediabetic kidney diseasediabetic nephropathyfocal segmental glomerulosclerosistransient receptor potential canonical channeltransient receptor potential cation channelMore Related Videos
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