Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis-A Survey

Area of Science:

• Biomechanics
• Computational Mechanics
• Medical Engineering

Background:

• Patient-specific bone fracture modeling is crucial for clinical applications.
• Existing literature lacks a unified framework for simulation and risk analysis.
• Interdisciplinary collaboration is needed from biology, medicine, physics, and engineering.

Purpose of the Study:

• To provide an up-to-date literature survey on patient-specific bone fracture modeling, simulation, and risk analysis.
• To propose a framework for realistic patient-specific bone fracture simulations.
• To serve as a starting point for researchers and practitioners.

Main Methods:

• Comprehensive bibliographical reference collection.
• Categorization of literature within a continuum mechanics framework.
• Review of computational modeling, property estimation, boundary conditions, and multiscale approaches.

Main Results:

• A structured overview of current research in bone fracture simulation.
• Identification of key areas including continuum modeling, computational geometry, material properties, and boundary conditions.
• Emphasis on multiscale modeling and experimental validation for improved accuracy.

Conclusions:

• The survey provides a foundation for advancing patient-specific bone fracture simulations.
• It highlights the importance of integrating computational mechanics with biological and medical data.
• Further research is needed to refine multiscale modeling and risk assessment techniques.