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Endoplasmic reticulum stress in autoimmune diseases
Qi Liu1, Heinrich Körner1, Huaxun Wu1
1Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation, China; Center of Anti-inflammatory and Immune Medicine, Hefei, 230032, Anhui Province, China.
Immunobiology
|December 28, 2019
Summary
Autoimmune diseases involve the immune system attacking the body. This review explores the link between autoimmune conditions and endoplasmic reticulum stress, particularly the unfolded protein response.
Area of Science:
- Immunology and Molecular Biology
- Cellular Stress Responses
Background:
- Autoimmune diseases are characterized by the immune system mistakenly attacking the body's own tissues.
- Chronic inflammation is a common feature in the development of autoimmune pathologies.
- Endoplasmic reticulum stress is increasingly recognized as a factor in inflammatory responses.
Purpose of the Study:
- To review current research on the connection between autoimmune diseases and endoplasmic reticulum stress.
- To specifically examine the role of the unfolded protein response (UPR) in this relationship.
Main Methods:
- Literature review of existing studies.
- Analysis of research on endoplasmic reticulum stress and autoimmune disease mechanisms.
Main Results:
- Endoplasmic reticulum stress is correlated with the development of inflammatory responses.
- The unfolded protein response (UPR) is a key pathway involved in this correlation.
Conclusions:
- Understanding the interplay between endoplasmic reticulum stress and the UPR is crucial for autoimmune disease research.
- Further investigation into these mechanisms may reveal new therapeutic targets for autoimmune conditions.
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