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Relationship between optic disc hemorrhage and corneal hysteresis
Nathan M Radcliffe1, Nathaniel Tracer2, Carlos Gustavo V De Moraes3
1Mt Sinai School of Medicine, New York, NY.
Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|December 28, 2019
Summary
Lower corneal hysteresis (CH) and greater vertical cup-to-disc ratio (VCDR) are linked to optic disc hemorrhage (DH). This suggests CH may indicate optic nerve abnormalities associated with glaucoma progression.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Corneal Biomechanics
Background:
- Optic disc hemorrhage (DH) is a clinical sign associated with glaucoma.
- Corneal hysteresis (CH) measures corneal biomechanical properties and is a risk factor for glaucoma.
- The relationship between DH and CH requires further investigation.
Purpose of the Study:
- To determine the association between corneal hysteresis (CH) and optic disc hemorrhage (DH).
Main Methods:
- A study of 49 patients with unilateral DH was conducted.
- Corneal hysteresis (CH) was measured using the Ocular Response Analyzer.
- Ocular parameters including intraocular pressure (IOP), central corneal thickness (CCT), and vertical cup-to-disc ratio (VCDR) were analyzed.
Main Results:
- Eyes with DH exhibited significantly lower CH compared to fellow eyes.
- Higher IOP and greater VCDR were also observed in eyes with DH.
- Multivariate analysis revealed CH and VCDR as independent predictors of DH laterality.
Conclusions:
- Lower CH is independently associated with the presence of DH.
- CH may serve as a structural biomarker for optic nerve abnormalities potentially linked to glaucoma progression.
- These findings highlight the potential role of corneal biomechanics in understanding optic nerve damage in glaucoma.
