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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
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Polypoidal choroidal vasculopathy in Canada.

Wai-Ching Lam1, Netan Choudhry2, David Wong3

  • 1Department of Ophthalmology, The University of Hong Kong, Hong Kong, Hong Kong; Department of Ophthalmology and Vision Sciences, University of Toronto, Unity Health Toronto, St. Michael's Hospital, Toronto, Ont..

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|December 28, 2019
PubMed
Summary
This summary is machine-generated.

Polypoidal choroidal vasculopathy (PCV), an AMD subtype more common in Asians, risks vision loss if untreated. Canadian diagnosis and treatment of PCV may be suboptimal, often involving anti-VEGF monotherapy.

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Area of Science:

  • Ophthalmology
  • Retinal diseases

Background:

  • Polypoidal choroidal vasculopathy (PCV) is an exudative subtype of age-related macular degeneration (AMD), prevalent in Asian populations.
  • Untreated PCV can cause significant vision impairment.
  • PCV may be underdiagnosed in Canada, leading to inappropriate treatment and poor outcomes.

Purpose of the Study:

  • To review the diagnosis and treatment of PCV in Canada.
  • To highlight potential underdiagnosis and treatment gaps.

Main Methods:

  • Multimodal imaging, including optical coherence tomography (OCT) and OCT angiography, aids PCV diagnosis.
  • Indocyanine green angiography (ICGA) is the gold standard but not widely used in Canada.
  • Treatment strategies include anti-vascular endothelial growth factor (anti-VEGF) agents and photodynamic therapy (PDT).

Main Results:

  • Recent trials indicate combination therapy (ranibizumab with PDT) or aflibercept monotherapy can be effective.
  • Canadian treatment patterns appear to favor anti-VEGF monotherapy, with or without PDT.

Conclusions:

  • Accurate diagnosis of PCV using multimodal imaging is crucial.
  • Current Canadian treatment practices may not align with the most effective evidence-based therapies.
  • Further research and improved diagnostic accessibility are needed to optimize PCV patient care in Canada.