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Risperidone-induced retrograde ejaculation and lurasidone may be the alternative.

Natarajan Shanmugasundaram1, J Nivedhya1, Murugan Selvaraj Karthik1

  • 1Department of Psychiatry, Sri Ramachandra Medical College and Research Institute, SRIHER, Chennai, Tamil Nadu, India.

Industrial Psychiatry Journal
|December 28, 2019
PubMed
Summary

Antipsychotic medication adherence suffers due to side effects like sexual dysfunction. Switching from risperidone to lurasidone resolved retrograde ejaculation in a schizophrenia patient, highlighting the need for proactive sexual health assessment.

Keywords:
Antipsychoticlurasidoneretrograde ejaculationrisperidonesexual dysfunction

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • Medication adherence is crucial for managing schizophrenia.
  • Antipsychotic medications can cause adverse effects, impacting patient compliance.
  • Sexual dysfunction is a common, yet often underreported, side effect of antipsychotics.

Observation:

  • A 35-year-old male with schizophrenia experienced sexual dysfunction, specifically retrograde ejaculation, after restarting risperidone therapy at 8 mg/day.
  • The patient had a history of sexual dysfunction with previous risperidone treatment.
  • Symptoms resolved upon cross-tapering from risperidone to lurasidone.

Findings:

  • Switching antipsychotic medication can effectively manage treatment-emergent sexual dysfunction.
  • Lurasidone appears to be a viable alternative for patients experiencing sexual side effects with risperidone.
  • Early identification and management of sexual dysfunction are key to improving antipsychotic adherence.

Implications:

  • Clinicians should routinely screen for sexual dysfunction in patients on atypical antipsychotics.
  • Tailoring pharmacological interventions, such as medication changes, can improve treatment outcomes and adherence.
  • Addressing sexual side effects is essential for comprehensive schizophrenia care and patient well-being.