Related Experiment Video
Updated: Jan 1, 2026
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
Expression pattern of Syndecan-1 and HSP-70 in hip tissue of patients with osteoarthritis
Julian Kaufman1, Davor Caric2, Katarina Vukojevic1
1Department of Anatomy, Histology and Embryology. School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia.
Objectives:
We investigated the expression of Syndecan-1 and HSP-70 in synovial, chondral and subchondral tissue in the hips of patients with osteoarthritis (OA).
Methods:
Total hip arthroplasty was performed on 6 patients and 3 controls. Patients were divided into two groups according to disease severity. The tissues were immunohistochemically analyzed.
Results:
Cartilage and subchondral tissue in patients with severe OA contained abundant positive cells with a mean positive percentage of 94,51 ± 5% and 78,95 ± 14% for Syndecan-1 and 94,42 ± 5% and 75,67 ± 17% for HSP-70, respectively.
Conclusion:
In conclusion, HSP-70 and Syndecan-1 might play a role in the onset and regulation of OA in the hip.
