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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Association of Left Atrial Appendage Voltage with Ischemic Stroke in Patients with Atrial Fibrillation

Binhao Wang1, Huimin Chu1, Bin He1

  • 1Arrhythmia Center, Ningbo First Hospital, Ningbo, Zhejiang, China.

Acta Cardiologica Sinica
|December 28, 2019
PubMed

Insights

Lower left atrial appendage voltage (LAAV) in patients with atrial fibrillation (AF) is linked to a higher risk of ischemic stroke. This finding suggests LAAV could help predict stroke in AF patients.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Low atrial voltage is a known risk factor for stroke.
  • The specific association between left atrial appendage voltage (LAAV) and ischemic stroke in atrial fibrillation (AF) patients was previously unknown.
  • Investigating LAAV may offer new insights into stroke risk stratification in AF.

Purpose of the Study:

  • To determine the relationship between LAAV and the prevalence of ischemic stroke in patients with AF.
  • To assess the predictive value of LAAV for ischemic stroke in this population.

Main Methods:

  • 1108 AF patients undergoing catheter ablation were analyzed.
  • Patients were categorized into stroke and control groups based on neuroimaging.
  • LAAV was measured using a circular mapping catheter; logistic regression analyzed the association with stroke.

Main Results:

  • 10.8% of patients had a history of ischemic stroke.
  • The stroke group exhibited lower LAAV (5.3 ± 1.8 mV vs. 6.5 ± 1.8 mV, p < 0.001).
  • Lower LAAV was independently associated with increased stroke prevalence (OR = 0.75; 95% CI 0.65-0.87; p < 0.001) with good predictive value (AUC = 0.83).

Conclusions:

  • Reduced LAAV in AF patients is significantly associated with a higher prevalence of ischemic stroke.
  • LAAV demonstrates potential as a biomarker for stroke risk in AF.
  • Further research is needed to confirm LAAV's role in predicting incident stroke.
Abstract

Keywords:
Atrial fibrillationIschemic strokeLeft atrial appendageVoltage

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