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Pathophysiological Functions of the lncRNA TUG1
Chong Guo1, Yuying Qi1, Jiayuan Qu1
1Department of Biochemistry, China Three Gorges University, Yichang City Hubei Province, China.
Current Pharmaceutical Design
|December 28, 2019
Summary
Long non-coding RNA taurine-upregulated gene 1 (TUG1) is implicated in various human diseases, including cancer. This review explores TUG1's molecular mechanisms and its potential as a diagnostic biomarker and therapeutic target.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Long non-coding RNAs (lncRNAs) play crucial roles in cellular functions and disease pathogenesis.
- Long non-coding RNA taurine-upregulated gene 1 (TUG1) is a key lncRNA involved in diverse physiological and pathological processes.
- TUG1's involvement spans epigenetic, transcriptional, and post-transcriptional gene regulation.
Purpose of the Study:
- To review and analyze the latest findings on the molecular mechanisms of TUG1 in various human diseases.
- To explore the physiological and pathophysiological roles of TUG1.
- To highlight TUG1's diagnostic and therapeutic potential.
Main Methods:
- Systematic review of research articles published in PubMed over the last six years.
- Keywords used: lncRNA and TUG1.
- Analysis focused on studies detailing TUG1's involvement in human diseases.
Main Results:
- TUG1 exhibits dysregulated expression in numerous human diseases, particularly malignancies.
- TUG1 dysregulation impacts cancer cell proliferation, migration, cell cycle, apoptosis, and drug resistance, suggesting an oncogenic role.
- TUG1's functions in endocrinology, metabolism, immunology, and neurobiology are also highlighted, with some studies showing downregulation in lung cancer.
Conclusions:
- Long non-coding RNA-TUG1 serves as a potential disease biomarker and therapeutic target.
- TUG1 has significant diagnostic and therapeutic applications in human cancers and cardiovascular diseases.
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