MiR-143HG Gene Polymorphisms as Risk Factors for Gastric Cancer in Chinese Han Population

Area of Science:

• Genetics
• Oncology
• Molecular Biology

Background:

• Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide.
• MicroRNAs (miRNAs) play a crucial role in cancer development and progression.
• The microRNA-143 host gene (miR-143HG) is implicated in various cancers, but its association with GC risk requires further investigation.

Purpose of the Study:

• To investigate the potential correlation between single-nucleotide polymorphisms (SNPs) in the miR-143HG and the risk of developing gastric cancer.
• To analyze the association of specific miR-143HG SNPs with GC susceptibility in the Han Chinese population.

Main Methods:

• Genotyping of 5 single-nucleotide polymorphisms (SNPs) in miR-143HG among 506 GC patients and 500 healthy controls.
• Application of multiple genetic models, stratification analysis, and haplotype analysis to assess the association between miR-143HG polymorphisms and GC risk.
• Calculation of odds ratios (ORs) and 95% confidence intervals (CIs) to quantify the risk associated with each SNP.

Main Results:

• The SNP rs11168100 was associated with a decreased risk of GC under codominant and dominant models.
• The SNP rs353300 was associated with an increased risk of GC under the recessive model.
• Several SNPs showed differential associations with GC risk based on age, sex, and lymph node metastasis status, with rs353300 exhibiting dual roles in females.

Conclusions:

• This study provides novel evidence for the association between miR-143HG polymorphisms and gastric cancer risk in the Chinese Han population.
• Specific SNPs within miR-143HG may influence individual susceptibility to GC, highlighting their potential as biomarkers.
• Further research is warranted to elucidate the functional mechanisms underlying these genetic associations in GC pathogenesis.