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Aviation gasoline: comparative subchronic nephrotoxicity study in the male rat
1Département de médecine du travail et d'hygiène du milieu, Université de Montréal, Québec, Canada.
Toxicology Letters
|November 1, 1988
Abstract:
Biochemical and histopathologic parameters of nephrotoxicity were measured in groups of male Fischer-344 rats after a 2-week, 5-days-a-week schedule of oral administration (0.5 ml/kg) of the following substances: aviation gasoline (grade 100) (AVG), automobile regular unleaded gasoline (ULG) and 2,2,4-trimethylpentane (TMP). Results of renal histopathologic examinations and biochemical parameters were compatible with the following order of increasing nephrotoxicity: ULG less than TMP less than AVG. The high nephrotoxic potential of aviation gasoline may be related to its elevated content in branched hydrocarbons.