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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
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Preimplantation Genetic Testing for Aneuploidy: A Review
James M Kemper1, Beverley J Vollenhoven2, Alon J Talmor3
1Doctor.
Obstetrical & Gynecological Survey
|December 28, 2019
Summary
Preimplantation genetic testing for aneuploidy (PGT-A) shows improved outcomes with newer technologies, reducing miscarriages. Case-by-case assessment is advised, utilizing blastocyst biopsy and next-generation sequencing for PGT-A.
Area of Science:
- Reproductive Medicine
- Genetics
- Embryology
Background:
- Preimplantation genetic testing for aneuploidy (PGT-A) has evolved significantly with advancements in biopsy techniques, timing, and genetic analysis.
- Despite technological progress, inconsistent evidence regarding PGT-A's efficacy has led to ongoing debate about its widespread clinical application.
Observation:
- Early PGT-A implementations did not consistently demonstrate improved pregnancy outcomes.
- Recent technological advancements, including blastocyst biopsy and next-generation sequencing, suggest PGT-A may offer superior results.
Findings:
- Newer PGT-A methodologies appear to reduce miscarriage rates and multiple gestations.
- The evidence base for PGT-A's effectiveness is still developing, with a need for more data on cumulative live birth rates.
Implications:
- PGT-A holds potential to enhance in vitro fertilization success rates.
- Clinicians and patients should individually evaluate the benefits of PGT-A.
- Laboratories should consider adopting advanced techniques like blastocyst biopsy and next-generation sequencing for PGT-A.
