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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
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Acute low-dose bisphenol S exposure affects mouse oocyte quality
Šárka Prokešová1, Kamar Ghaibour2, František Liška3
1Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Animal Science, Prague 10-Uhrineves, Czech Republic; Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.
Reproductive Toxicology (Elmsford, N.Y.)
|December 28, 2019
Summary
Bisphenol S (BPS) exposure harms mouse oocyte quality, causing DNA damage and abnormal spindle formation. These effects occur at low doses, indicating potential risks even below human exposure levels.
Area of Science:
- Reproductive toxicology
- Endocrinology
- Developmental biology
Background:
- Bisphenol S (BPS) is a common BPA replacement.
- Endocrine disruptors pose risks to reproductive health.
Purpose of the Study:
- Evaluate BPS effects on oocyte quality.
- Investigate BPS's impact via oral exposure.
Main Methods:
- In vivo BPS exposure in female mice (0.001–100 ng/g/day).
- Oocyte isolation and in vitro maturation.
- Analysis of spindle formation, DNA damage, and epigenetic marks (5meC, H3K27me2).
- Transcriptome analysis for embryonic development genes.
Main Results:
- BPS increased aberrant spindle formation and DNA damage in oocytes.
- Elevated 5meC and H3K27me2 marks observed with BPS exposure.
- Differential gene expression related to early embryonic development in BPS-exposed oocytes.
- Non-monotonic dose-response observed.
Conclusions:
- BPS negatively impacts oocyte quality.
- Effects observed at environmentally relevant concentrations.
- BPS may pose risks to female reproductive health.
