Behavioral and neural processes in counterconditioning: Past and future directions
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Updated: Jan 1, 2026

Pavlovian Conditioned Approach Training in Rats
Published on: February 4, 2016
Nicole E Keller1, Augustin C Hennings1, Joseph E Dunsmoor2
1University of Texas at Austin, Institute for Neuroscience, Austin, TX, 78712, USA.
Abstract:
Counterconditioning refers both to the technique and putative process by which behavior is modified through a new association with a stimulus of an opposite valence. Similar to extinction, counterconditioning is considered a form of inhibition that interferes with the expression of the originally learned response without erasing it. But whereas interest in extinction continues to rise, counterconditioning has received far less attention. Here, we provide an in-depth review of counterconditioning research and detail whether counterconditioning is any more effective than extinction at preventing relapse of the originally learned behavior. We consider the clinical implications of counterconditioning, describe recent neurobiological and neuroimaging research in this area, and consider future avenues in need of further investigation.
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