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Resistin and Cardiac Arrest-A Prospective Study.
Raluca M Tat1, Adela Golea2, Rodica Rahaian3
1Department of Anesthesia and Intensive Care I, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Journal of Clinical Medicine
|December 29, 2019
Summary
High resistin levels in cardiac arrest survivors are linked to post-cardiac arrest shock and cardiovascular comorbidities. Post-arrest shock significantly impacts resistin levels more than comorbidities.
Area of Science:
- Cardiology
- Biomarkers
- Critical Care Medicine
Background:
- Systemic response to ischemia-reperfusion after cardiac arrest (CA) causes endothelial toxicity and cytokine release.
- Resistin is an emerging biomarker for inflammation and myocardial injury, mediating endothelial dysfunction.
Purpose of the Study:
- To investigate associations between clinical/biological variables and serum resistin levels in CA survivors.
- To determine the predictive value of resistin levels in relation to patient outcomes.
Main Methods:
- Enrolled 40 out-of-hospital CA survivors, recording demographic, clinical, and laboratory data.
- Measured serum resistin levels at multiple time points (0-72 hours) and calculated Area Under the Curve (AUC).
- Utilized univariate and multivariate analyses to identify independent predictors of resistin levels.
Main Results:
- Fifteen patients (37.5%) died within 72 hours; 72.5% experienced post-CA shock.
- Univariate analysis showed age, resuscitation duration, SOFA score, lactate, comorbidities, and shock associated with higher resistin.
- Multivariate analysis identified post-CA shock and cardiovascular comorbidities as independent predictors of early resistin AUCs, with post-CA shock being the sole predictor for later AUCs.
Conclusions:
- High serum resistin levels correlate strongly and independently with cardiovascular comorbidities and post-CA shock in CA survivors.
- Post-CA shock has a greater impact on serum resistin concentrations than cardiac comorbidities.
