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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jan 1, 2026

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AVATAR: Analysis for Visual Acuity Prediction After Eye Interventional Radiotherapy.

Monica Maria Pagliara1, Luca Tagliaferri2, Jacopo Lenkowicz3,4

  • 1U.O.C. Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

In Vivo (Athens, Greece)
|December 29, 2019
PubMed
Summary

This study identified clinical factors predicting visual acuity loss after radiotherapy for uveal melanoma. A predictive model, the AVATAR nomogram, was developed to identify patients at risk of vision loss.

Keywords:
106RuPlaque brachytherapyinterventional radiotherapynomogramprediction modeluveal melanomavisual acuity

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Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Medical Imaging

Background:

  • Uveal melanoma is the most common primary intraocular malignancy.
  • Interventional radiotherapy, specifically 106Ru brachytherapy, is a standard treatment for uveal melanoma.
  • Predicting visual acuity loss is crucial for patient management and counseling.

Purpose of the Study:

  • To identify clinical factors that predict visual acuity loss following 106Ru brachytherapy for uveal melanoma.
  • To develop a predictive model to assist in identifying patients at high risk of vision impairment.
  • To create a decision support tool for treatment planning and patient counseling.

Main Methods:

  • Retrospective review of 152 patients treated with 106Ru plaque brachytherapy for primary uveal melanoma.
  • Development of a predictive nomogram to estimate visual acuity loss at 3 years post-treatment.
  • Statistical analysis to identify factors correlated with visual acuity outcomes.

Main Results:

  • The actuarial probability of maintaining 20/40 vision or better was 0.54 at 5 years post-treatment.
  • Factors positively correlated with visual acuity loss included older age at treatment initiation and larger tumor basal diameter.
  • Tumor proximity to the foveola was inversely correlated with visual acuity loss, indicating a protective effect.

Conclusions:

  • Clinical factors such as age, tumor size, and proximity to the foveola can predict visual function after radiotherapy for uveal melanoma.
  • The developed AVATAR nomogram serves as a valuable tool for predicting visual acuity outcomes.
  • This predictive model can aid clinicians in identifying at-risk patients and optimizing treatment strategies.