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Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
Bartosz Jura1, Nathalie Macrez2,3, Pierre Meyrand2,3,4
1Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 02-109, Warsaw, Poland.
Scientific Reports
|December 29, 2019
Summary
Alzheimer
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Systems Neuroscience
Background:
- Declarative memory relies on hippocampal-cortical interactions, with ripples facilitating consolidation.
- Alzheimer disease (AD) impairs memory formation, but network-level changes remain unclear.
Purpose of the Study:
- Investigate network activity alterations in Alzheimer disease models.
- Unravel changes in hippocampal and cortical ripples during spatial memory processing.
Main Methods:
- Utilized freely moving APP/PS1 mice (an AD model) and wild-type littermates.
- Recorded hippocampal and cortical activity during spatial memory encoding and consolidation.
- Analyzed ripple occurrence and network dynamics.
Main Results:
- APP/PS1 mice consolidated spatial memory despite reduced hippocampal ripple rates and impaired learning-dependent dynamics.
- Observed a compensatory increase in cortical ripple occurrence in APP/PS1 mice.
- Evidence suggests reorganization of cortical-hippocampal interactions.
Conclusions:
- Network-level compensatory mechanisms may preserve spatial memory consolidation in AD models.
- Cortical activity and altered network interactions might mitigate hippocampal deficits.
- Further research into these compensatory strategies is warranted.
